Rheumatoid Arthritis and Treatment of Periodontitis: a Randomized Clinical Trial.

University of Pisa

Status: Completed

Conditions: Periodontitis; Arthritis, Rheumatoid

Treatments: Procedure: Immediate non-surgical periodontal treatment and oral hygiene instructions

Study type: Interventional

Funder types: Other

Identifiers

NCT05271890

Perioreuma

Details and patient eligibility

About

Periodontitis is an infectious disease defined by bacteria-mediated inflammation of the supporting tissues of the teeth that if left untreated may ultimately lead to the destruction of the attachment apparatus, culminating in tooth loss. Rheumatoid arthritis is a chronic destructive inflammatory disease characterized by autoantibodies and the accumulation and persistence of an inflammatory infiltrate in the synovial membrane that leads to synovitis and the destruction of the joint architecture. The objective of this study was to evaluate the possible beneficial additional value of non-surgical periodontal therapy on systemic markers of inflammation and clinical and serological parameters of rheumatoid arthritis.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects affected by rheumatoid arthritis with a stable therapeutic regimen for at least 3 months preceding the study participation
• Subjects with at least 15 teeth
• Subjects affected by severe generalized periodontitis that had undergone no periodontal treatment in the 6 months preceding the study participation

Exclusion criteria

• Age younger than 18 years
• Pregnancy or breastfeeding
• Edentulism
• Diagnosis of other autoimmune pathologies, liver disease, diabetes, early/juvenile arthritis or syndromes associated with RA

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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30 participants in 2 patient groups

Immediate periodontal treatment

Experimental group

Description:

Subjects assigned to this group were receiving non-surgical periodontal treatment as well as oral hygiene instructions immediately after their inclusion. All subjects were undergone full periodontal and rheumatologic clinical examinations both at baseline and 90 days after the completion of the treatment. Blood collection for the analysis of the serum concentration of CRP, ESR, Fibrinogen, IL-6 and TNF-α was also performed at baseline and 90 days after periodontal treatment.

Treatment:

Procedure: Immediate non-surgical periodontal treatment and oral hygiene instructions

Delayed periodontal treatment

No Intervention group

Description:

Subjects assigned to this group were receiving non-surgical periodontal treatment 90 days after baseline evaluation. All subjects were undergone full periodontal and rheumatologic clinical examinations both at baseline and 90 days after. Blood collection for the analysis of the serum concentration of CRP, ESR, Fibrinogen, IL-6 and TNF-α was also performed at baseline and 90 days after.