Rheumatoid Arthritis Patients and Porphyromonas Gingivalis

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Rheumatoid Arthritis

Treatments: Procedure: synovial tissue; Procedure: blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT02905175

2014-A01688-39 (Other Identifier)

1408022

Details and patient eligibility

About

Rheumatoid arthritis (RA) is the most frequent joint inflammatory disease inducing joint destruction strongly correlated with anti-citrullinated protein antibodies citrullinated anti-peptide (ACPA). Precise RA etiology remained unclear with a described association between RA and periodontal disease. The missing link could be a gram-negative anaerobic bacterium called Porphyromonas gingivalis (P. gingivalis), which is heavily involved in periodontal disease and able to induce gingival citrullinated protein via an enzyme called peptidyl arginine deiminase (PAD). DNA of P. gingivalis was detected in synovial tissue and in peripheral blood mononuclear cell. To improve knowledge of P. gingivalis involvement in RA, the investigators will compare its effect on various cell type with comparison with another oral bacteria Provatella intermedia.

Enrollment: 11 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18 ans
• RA or osteoarthritis with joint surgery planned
• Informed consent approved and signed

Exclusion criteria

• Pregnancy

Trial design

11 participants in 2 patient groups

Rheumatoid arthritis

Description:

blood sample specimen and synoviocytes from synovial tissue

Treatment:

Procedure: blood sample

Procedure: synovial tissue

Osteoarthritis

Description:

blood sample specimen and synoviocytes from synovial tissue

Treatment:

Procedure: blood sample

Procedure: synovial tissue