Rhinopharyngeal Retrograde Clearance is Effective to Adequate Upper Airways Function in Adults

University of Sao Paulo

Status: Completed

Conditions: Nasal Obstruction; Exposure to Pollution

Treatments: Other: rhinopharyngeal retrograde clearance (RRC)

Study type: Interventional

Funder types: Other

Identifiers

NCT01976039

CEP-FMUSP 211-11

Details and patient eligibility

About

Professionals working in polluted areas may present increased clinical airways symptoms and dysfunction. Rhinopharyngeal retrograde clearance (RRC) has been used to improve mucus clearance in infants with bronchitis and bronchiolitis, and instillation the nasal cavity with saline has been used to reduce nasal inflammation in rhinitis and sinusopathies. The aim of this study was to assess the effects of RRC and RCC combined with saline (RRC+S) on nasal mucociliary clearance (MCC), mucus surface property, cellularity and airways symptoms in professional motorcyclists.

Full description

Male motorcyclists (mean age 36 years) were recruited and randomly assigned to RRC or RRC+S. Subjects were assessed at baseline and 15 days after interventions for saccharin test, mucus contact angle, cellularity in nasal lavage and airways symptoms with the use of SNOT-20 questionnaire. Data were analyzed by two-way ANOVA for repeated measures with Bonferroni´s correction. A passive monitoring-system of nitrogen dioxide was used to assess the individual air pollution exposure along the study period. The association between nitrogen dioxide and the airways outcomes was analyzed by Spearman correlation test.

Enrollment: 24 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Professional motorcyclists aged 18 years to 45 years
• Minimum of one year in that occupation
• Agreement with the written informed consent

Exclusion criteria

• Smokers
• Inability to understand and to follow commands
• Previous nasal surgery
• Respiratory infection in the previous 30 days

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

24 participants in 2 patient groups

RRC

Other group

Description:

rhinopharyngeal retrograde clearance (RRC) isolated: First patient sits in a chair. Second: patient inhales air deeply and exhales making noise and vibration in the upper airway to facilitate swalling. Third patients finishes with another deep inhalation. This technique is new, simple to use and with no cost. No need of any material or equipment.

Treatment:

Other: rhinopharyngeal retrograde clearance (RRC)

RRC+S

Experimental group

Description:

retrograde rhinopharyngeal retrograde clearance combined with saline instillation (RRC+S): patient sits in a chair and inhaled air and make noise and vibrate the upper airway at the same instills saline into the nare to facilitate nose washing and swalling. This technique is new, simple to use and with low cost (only saline).

Treatment:

Other: rhinopharyngeal retrograde clearance (RRC)