Rhythm Experience and Africana Culture Trial (REACT)

University of Pittsburgh

Status: Completed

Conditions: Brain Structure; Cognitive Performance

Treatments: Behavioral: African Dance; Behavioral: African Cultural Immersion

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03771716

STUDY19020263

1R01AG060741-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

REACT is a randomized intervention to examine the benefits of African Dance as a method to increase physical activity behaviors in older adults. In this 6- month intervention, older African Americans will be randomly assigned to either an African Dance or an Africana Culture class. Both before and at the completion of the intervention, the investigators will collect a comprehensive neuropsychological battery and MRI scans of brain health and function to better study how physical activity influences neurocognitive health in African Americans.

Full description

Aim 1: Examine whether the African Dance intervention improves cognitive performance compared to an educational control group. H1: The dance group will show cognitive improvements in a domain-specific fashion such that executive and memory functions will be enhanced more than other cognitive domains; Aim 2. Examine whether African Dance influences brain morphology, task-evoked neural responses, cerebral blood flow, and resting state connectivity. H1: It is predicted that African Dance will increase volume, white matter integrity, perfusion, and functional activation/connectivity in a regionally-specific fashion such that prefrontal and hippocampal areas will be more sensitive to the intervention than other brain regions. Aim 3. Explore potential physiological and socio-emotional mechanisms of the dance intervention. The investigators will collect measures of physical and psychosocial health such as waist circumference, blood pressure, blood glucose and lipid levels, mood, anxiety, depression, and loneliness and examine whether intervention-related changes to these measures mediate improvements in cognitive performance.

Enrollment: 151 patients

Sex: All

Ages: 60 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• self identifies race as African American
• between 60 and 80 years of age
• ambulatory without pain or the assistance of walking devices
• no history of falls or balance problems
• able to speak and read English
• available during the times classes are offered and able to make at least 80% of classes (e.g., no long-term travel plans)
• reliable means of transportation
• scores above the range on the Brief Telephone Interview for Cognitive Status (TICS) indicative of moderate to severe cognitive impairment (scores 21 or above)
• no diagnosis of a neurological disease or psychiatric conditions
• eligible to undergo MRI (not claustrophobic and no metal or history of injury involving metal).
• Fully vaccinated for coronavirus disease (COVID-19).

Exclusion criteria

• self identifies race as other than African American
• not between 60 and 80 years of age
• not ambulatory without pain or the assistance of walking devices
• history of falls or balance problems
• unable to speak and read English
• unavailable during the times classes are offered or unable to make at least 80% of classes (e.g., indicates long-term travel plans during intervention period)
• no reliable means of transportation
• scores in range on the TICS indicative of moderate to severe cognitive impairment (scores 21 or below)
• has a diagnosis of a neurological disease or psychiatric condition
• ineligible to undergo MRI (claustrophobic and/or metal in body or history of injury involving metal).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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151 participants in 2 patient groups

African Dance

Experimental group

Description:

This is the experimental group. Dance classes will be held 3 times per week for 1 hour. Participants will learn traditional Africana dance moves and sequences.

Treatment:

Behavioral: African Dance

African Cultural Immersion

Active Comparator group

Description:

This is the active control group. Participants will participate in a variety of educational activities related to African Culture, including traditional cooking, lectures, crafts, music and films. They will meet 3 times per week for the same duration as the Dance group. However, they will not participate in aerobic activity during the classes, and most activities will be conducted in a seated position.

Treatment:

Behavioral: African Cultural Immersion