RIC (Remote Ischemic Conditioning) in Older Individuals

Duke University

Status: Invitation-only

Conditions: Old Age; Debility; Mobility Limitation

Treatments: Other: Low-Dose Remote ischemic conditioning (RIC); Other: Low-intensity resistance exercise training; Other: High-Dose Remote ischemic conditioning (RIC)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT06476288

Pro00115014

Details and patient eligibility

About

The purpose of this study is to examine the feasibility and acceptability of a technique called remote ischemic conditioning (RIC) that aims to improve muscle strength, muscle mass, exercise tolerance, resilience (i.e. how well someone responds to a stressor), quality of life, physical activity, and physical function when added to rehabilitative exercise training in individuals over age 65 who have some difficulty with mobility.

Enrollment: 20 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age: ≥ 65 years and referred to an exercise program for functional decline, deconditioning, or fall risk
2. Exercises ≤ 2x/week on a regular interval

Exclusion criteria

1. Unstable heart disease as determined by the investigator or study physician
2. History of any orthopaedic, neurologic, or metabolic condition that would contraindicate exercise testing/training as determined by the investigator
3. Cognitive inability to follow directions and safely participate in exercise

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups, including a placebo group

High-Dose RIC (Remote Ischemic Conditioning) Intervention

Active Comparator group

Description:

Low-intensity resistance exercise training plus high-dose RIC.

Treatment:

Other: High-Dose Remote ischemic conditioning (RIC)

Other: Low-intensity resistance exercise training

Low-Dose RIC Intervention

Placebo Comparator group

Description:

Low-intensity resistance exercise training plus low-dose RIC.

Treatment:

Other: Low-Dose Remote ischemic conditioning (RIC)

Other: Low-intensity resistance exercise training