Ridge Preservation Using Guided Regenaration, Platelet-rich Plasma and Free Gingival Grafts

Medical University of Varna

Status: Completed

Conditions: Post-Extraction Socket Healing; Ridge Preservation

Treatments: Procedure: Ridge preservation technique; Procedure: ridge preservation

Study type: Interventional

Funder types: Other

Identifiers

NCT06621498

118/23.06.2022

Details and patient eligibility

About

The goal of this clinical trial is to learn if ridge preservation methods with dense polytetrafluoroethylene membranes, with d-PTFE membranes and platelet-rich plasma, and with free gingival grafts can reduce vertical resorption of the post-extraction socket walls.

Researchers compared each experimental group to a control group (unassisted socket healing). Participants were randomly allocated to one of the four groups.

Cone-beam computed tomography was performed after the procedure and 3 months post-operatively to evaluate the vertical socket wall resorption.

Enrollment: 80 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients in the age group 18-65 years;
2. Patients in good general condition;
3. Patients requiring extraction of premolars or molars;
4. Patients in whom restoration of the missing tooth with a dental implant and/or prosthetic construction is planned;
5. Signed informed consent to participate in the study.

Exclusion criteria

1. Patients with contraindications for general surgical treatment:

   • patients with uncontrolled arterial hypertension;
   • patients with uncontrolled metabolic diseases;
   • patients with AMI in the last 6 months;
   • patients on hemodialysis treatment;
   • patients who underwent chemotherapy and/or radiotherapy in the last year;
   • patients on immunosuppressive therapy;
   • patients on anti-resorptive and anti-angiogenic therapy;
   • patients with concomitant acute diseases at the time of the study;
   • patients with proven psychiatric diseases;
   • pregnancy.

2. There are local contraindications:

   • insufficient volume of bone after the extraction to carry out RP;
   • acute inflammatory disease or tumor process in the area;

3. Lack of informed consent.

4. Lack of patient motivation for the treatment.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 4 patient groups

Ridge preservation with dense polytetrafluoroethylene membrane

Experimental group

Description:

Tooth extraction and ridge prservation with dense PTFE membrane to cover the socket was used in this group.

Treatment:

Procedure: Ridge preservation technique

Ridge preservation with dense polytetrafluoroethylene membrane and platelet-rich plasma

Experimental group

Description:

Tooth extraction and ridge prservation with dense PTFE membrane and autologous PRP was used in this group.

Treatment:

Procedure: ridge preservation

Procedure: ridge preservation

Ridge preservation with free gingival grafts

Experimental group

Description:

Tooth extraction and ridge prservation with autologous free gingival grafts as a method for socket sealing was used. Donor sites were the hard palate and the maxillary tuberosity.

Treatment:

Procedure: ridge preservation

Procedure: ridge preservation

Control group

No Intervention group

Description:

Tooth extraction without ridge preservation.