Right Side of Heart Function After Lung Surgery

University of Glasgow

Status: Unknown

Conditions: Ventricular Failure, Right; Lung Cancer

Treatments: Procedure: Lung resection

Study type: Observational

Funder types: Other

Identifiers

NCT01892800

1-shelly

Details and patient eligibility

About

The purpose of this study is explore the impact of lung cancer surgery on the function of the right side of the heart.

Full description

Lung cancer is the second most common cancer in the UK. In suitable cases the best chance of cure is surgical resection. Studies suggest that lung resection is associated with right ventricular (RV) dysfunction, predisposing to complications and post-operative dyspnoea. Studies of RV function following lung resection have been hampered by the limitations of the techniques used. In addition the mechanism of RV dysfunction has remained elusive.

In this prospective observational study the RV response to lung resection will be characterised by sequential assessment of right ventricular ejection fraction (RVEF) measured using cardiovascular magnetic resonance (CMR). CMR is non-invasive, involves no ionising radiation and due to its high spatial resolution is the gold standard for assessing RV volumes. Comprehensive CMR and echocardiographic assessment of the pulmonary vascular - RV axis will allow us to interpret peri-operative changes in RVEF in the context of RV contractility and loading indices. In addition, contemporaneous blood samples will be taken for measurement of biomarkers of myocardial and endothelial dysfunction and systemic inflammation.

With increased understanding of the mechanisms involved, it may be possible to prevent RV dysfunction; reducing complication rates, hospital stay and costs and ameliorating long term dyspnoea.

Enrollment: 25 estimated patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Provision of informed consent
2. Age >16 years
3. Planned elective lung resection by lobectomy

Exclusion criteria

1. Pregnancy

2. On-going participation in any investigational research which could undermine the scientific basis of the study

3. Contraindications to magnetic resonance imaging:

   i. Cardiac pacemaker, artificial heart valve, neurostimulator, cochlear implant ii. Aneurysm clips iii. Metal injuries to the eye iv. Loose metal in an part of the body

4. Wedge / segmental / sub-lobar lung resection

5. Pneumonectomy

6. Isolated right middle lobectomy

Trial design

25 participants in 1 patient group

Study population - lung resection

Description:

Patients with suspected lung cancer undergoing lung resection by anatomic lobectomy

Treatment:

Procedure: Lung resection