Right Ventricular Function at Rest in Highlanders/Lowlanders

University of Zurich (UZH)

Status: Completed

Conditions: High Altitude Pulmonary Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT03165656

01-8/433A

Details and patient eligibility

About

The purpose of the current study is to evaluate the progression of right ventricular function and dimension in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross sectional case-control study.

Enrollment: 173 patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure >30 mmHg measured by echocardiography at altitude of residence.
• healthy subjects (high altitude controls)
• Both genders
• Age >16 y
• Kyrgyz ethnicity
• born, raised and currently living at >2500 m
• healthy subjects currently living at <1000 m (low altitude controls)

Exclusion criteria

• Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
• Excessive erythrocytosis
• Other coexistent disorders that may interfere with the cardio-respiratory system and sleep
• Regular use of medication that affects control of breathing
• Heavy smoking

Trial design

173 participants in 3 patient groups

High altitude pulmonary hypertension

Description:

Highlanders with high altitude pulmonary hypertension living above 2500 m.

High altitude control

Description:

Healthy highlanders living above 2500 m.

Low altitude control

Description:

Healthy lowlanders living below 1000 m.