Right Ventricular Function During Exercise in Highlanders/Lowlanders
Status
Completed
Conditions
High Altitude Pulmonary Hypertension
Details and patient eligibility
About
The purpose of the current study is to evaluate the right ventricular function during graded cycling on an ergometer by transthoracic echocardiography in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross-sectional case-control study.
Enrollment
173 patients
Sex
All
Ages
16+ years old
Volunteers
No Healthy Volunteers
Inclusion criteria
- high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure >30 mmHg measured by echocardiography at altitude of residence.
- healthy subjects (high altitude controls)
- Both genders
- Age >16 y
- Kyrgyz ethnicity
- born, raised and currently living at >2500 m
- healthy subjects currently living at <1000 m (low altitude controls)
Exclusion criteria
- Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
- Excessive erythrocytosis
- Other coexistent disorders that may interfere with the cardio-respiratory system and sleep
- Regular use of medication that affects control of breathing
- Heavy smoking
Trial design
173 participants in 3 patient groups
High altitude pulmonary hypertension
Description:
Highlanders with high altitude pulmonary hypertension living above 2500 m.
High altitude control
Description:
Healthy highlanders living above 2500 m.
Low altitude control
Description:
Healthy lowlanders living below 1000 m.
Trial contacts and locations
1
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Data sourced from clinicaltrials.gov
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