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About
The goals of this study were two-fold. First, the attempt to quantify the relationships between pulmonary arterial stiffness, right ventricular function and the efficiency of ventricular-vascular interactions in patients with pulmonary arterial hypertension (PAH). Second, the attempt to quantify the effects of exercise on pulmonary arterial stiffness, pulmonary vascular resistance, right ventricular function and the efficiency of ventricular-vascular interactions in patients with PAH.
Full description
The goals of this study are to quantify right ventricular-pulmonary vascular interactions in different types of PAH, to determine the temporal changes in these interactions with PAH progression and to quantify the effects of exercise on right ventricular function. The inclusion of the subpopulation of PAH patients with systemic sclerosis (SSc) was a result of the anticipation that this group has worse arterial stiffening than other groups, and consequently more inefficient right ventricular-pulmonary vascular interactions, which account for their worse prognosis.
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Inclusion criteria
Exclusion criteria
Recent syncope (within 1 year)
Severe skeletal or muscle abnormalities prohibiting exercise
Mixed etiology pulmonary arterial hypertension
Severe lung disease
Pregnancy or breastfeeding
NYHA class IV patient
Contraindications to magnetic resonance imaging
Kidney dysfunction as determined by an estimated glomerular filtration rate (eGFR) of < 30 mL/min/1.73m2
Contraindication to gadolinium
Primary purpose
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Interventional model
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14 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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