Rijavithi Viral and Mycobacterium PCR Arrays in CNS Infection Study (VIMPAC)

Rajavithi Hospital

Status: Completed

Conditions: CNS Viral Infection

Treatments: Other: LUMBAR PUNCTURE

Study type: Observational

Funder types: Other

Identifiers

NCT00807378

RH-CMR-004

Details and patient eligibility

About

This study of neurotropic viral infection and Tuberculous CNS infection is the comprehensive investigation of CSF PCR arrays (Hybrydiaztion technique,Sybergreen and Taqman real time PCR arrays of CSF ) in suspected cases of viral CNS infection, Tuberculous CNS infection in both AIDS and non AIDS patients.

Patients with clinical viral encephalitis and all meningoencephalitis including all patients with HIV/AIDS CSF and non AIDS will be banked and test for RNA and DNA viral sequence by Real time PCR arrays and IS6110 gene of Mycobacterium tuberculosis. Clinical data and final diagnosis will be used to analyze the result of this PCR arrays technique compared to clinical gold standard criteria.

Enrollment: 200 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. AGE MORE THAN 15 YRS
2. ABLE TO INFORM CONSENT BY THEMSELF OR THEIR PARENT
3. SUSPECTED CNS VIRAL INFECTION

Exclusion criteria

1. UNABLE/CONTRAINDICATED FOR LUMBAR PUNCTURE OR CSF COLLECTION
2. WITHDRAW CONSENT
3. SUSPECTED SEVERE OR VILURENT VIRAL INFECTION SUCH AS H5N1/SARS INFECTION

Trial design

200 participants in 2 patient groups

1

Description:

AIDS PATIENTS

Treatment:

Other: LUMBAR PUNCTURE

2

Description:

NON-AIDS PATIENTS

Treatment:

Other: LUMBAR PUNCTURE