RIPC and Platelet Activation on Platelet Activation During Cardiopulmonary Bypass

Seoul National University

Status: Completed

Conditions: Platelet Dysfunction

Treatments: Device: Sham control; Device: Remote ischemic preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT03458351

RIPC_platelet activation

Details and patient eligibility

About

In this study, the investigators are going to investigate the effects of remote ischemic preconditioning on platelet activation in patients undergoing cardiac surgery with cardiopulmonary bypass.

Full description

Previous studies reported that remote ischemic conditioning reduce platelet activation in patients with coronary artery disease or patients undergoing ablation for atrial fibrillation. Cardiac surgery with cardiopulmonary bypass has been associated with platelet activation. In this randomized study, investigators are going to compare the effects of remote ischemic preconditioning (RIPC) on platelet activation using flow cytometry in patients undergoing cardiac surgery with cardiopulmonary bypass.

Enrollment: 58 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing cardiac surgery with cardiopulmonary bypass

Exclusion criteria

• Preoperative left ventricle ejection fraction < 30%, mechanical ventricular support
• Peripheral vascular disease
• Poorly controlled diabetes mellitus
• NSAIDs within 3 days
• iv heparin within 6 h
• low molecular weight heparin within 24 h
• platelet inhibitor within 24 h
• known thrombocytopenia
• End stage renal disease / hemodialysis
• Active infection
• Pregnancy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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58 participants in 2 patient groups

Remote ischemic preconditioning

Active Comparator group

Description:

Remote ischemic conditioning after anesthesia induction - four cycles of 5 min of ischemia followed by 5 min of reperfusion by inflation to 200 mm Hg and deflation of a blood pressure cuff on the upper arm

Treatment:

Device: Remote ischemic preconditioning

Sham control

Sham Comparator group

Description:

The same blood pressure cuff is placed around the upper arm, but the cuff is inflated to 10mm Hg.

Treatment:

Device: Sham control