Risankizumab in Children With Crohn's Disease (RisaKids)

Shaare Zedek Medical Center

Status

Enrolling

Conditions

Crohn Disease

Treatments

Drug: Risankizumab

Study type

Interventional

Funder types

Other

Identifiers

NCT06298188

RisaKids

Details and patient eligibility

About

The goal of this observational study is to to prospectively explore the real life short (12 weeks) and longer term (54 weeks) clinical, biochemical and endoscopic outcomes of risankizumab in pediatric CD.

This is a 1-year prospective multi-center cohort study of children commencing on risankizumab for pediatric CD with 2 years extension for long-term follow-up. The investigators will record clinical manifestations, blood markers and fecal calprotectin, with monitoring for safety signals including infusion and injection site reactions, pyrexia and infections at various intervals as outlined below. The investigators will also include calprotectin monitoring and fecal sample collection for microbiome and serum samples for drug levels. According to available budget, the investigators will also collect fecal and serum samples for metabolome. Samples collection is optional, thus failure of bio-samples collection will not exclude patients from the study.

Enrollment

90 estimated patients

Sex

All

Ages

6 to 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Children under the age of 18 years,
Patients diagnosed with CD.
Patients commenced on risankizumab by treating physician (at least one dose), either alone or in combination with any other CD medications, at any stage of the disease.

Exclusion criteria

* There will be no exclusion criteria to this study.