Risk Analysis for Cardiovascular Autonomic Neuropathy

Tongji University

Status: Completed

Conditions: Cardiovascular Autonomic Neuropathy

Treatments: Other: not intervention

Study type: Observational

Funder types: Other

Identifiers

NCT02462616

CANRA_Dr.Tang

Details and patient eligibility

About

This is a large-scale, community-based, cross-sectional study to evaluate environmental and genetic risk factors for cardiovascular autonomic neuropathy in general Chinese population.

Full description

A large-scale, community-based, cross-sectional study was conducted to explore the extent to which risk factors associated with cardiovascular autonomic neuropathy (CAN) in general Chinese population. A total of more than 2000 participants were recruited by using multiple stages sampling (first cluster sampling and then simply sampling). Data involved in demographic information, clinical biomarkers such as glucose and lipids profiles, medical and therapy history were collected. Every participants was complete DNA extracted and genotyped. Cardiovascular autonomic functions were measured by using short-term heart rate variability (HRV) to evaluate the outcome of CAN. Univariate and multiple variables analysis have been performed to examine potential environmental and genetic risk factors of CAN. In addition, clinical risk model, simply screening model and non-linear system model such as artificial neural network was created, respectively.

Enrollment: 2,100 patients

Sex: All

Ages: 30 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Survey Chinese participants with undiagnosed CAN
• Aged 30-90 years, were included in this study.

Exclusion criteria

• Some subjects were excluded from the study to eliminate potential confounding factors that may have influenced their CA function. Briefly, the exclusion criteria were as follows:

  1. history or findings of arrhythmia and hyperthyroidism or hypothyroidism
  2. pregnancy or lactation
  3. serious hepatic or renal dysfunctions (GFR < 30 mL/min/1.73m2).

• Of these subjects, complete baseline data were obtained for 2,092 (69.46%) of the participants.

Trial design

2,100 participants in 1 patient group

Dr.Tang's research group

Description:

Dr.Tang's research group for clinical risk analysis of human complex disease

Treatment:

Other: not intervention