Risk and Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL) (MBL RiskConseq)

University of Haifa

Status: Not yet enrolling

Conditions: Alzheimer Disease; Monoclonal B-Cell Lymphocytosis; Parkinson Disease; Cardiovascular Diseases; Infections; Chronic Lymphocytic Leukemia; Cancers; Dementia; Autoimmune Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT06416267

MBL_RiskCons

Details and patient eligibility

About

The aim of this proposal is to identify immune biomarkers, genetic risk, and the clinical consequences of low count monoclonal B-cell lymphocytosis (LC MBL), a common premalignant condition affecting up to 17% of European adults age>40. LC MBL is a precursor to chronic lymphocytic leukemia (CLL), characterized by a circulating population of clonal B-cells. It is relatively understudied, despite emerging evidence of clinical consequences such as increased risk for life-threatening infections and lymphoid malignancies. Studies reported that male sex, age, family history of CLL, and CLL-susceptibility genetic loci were associated with LC MBL risk. These findings were reported in European ancestry individuals and have not been generalized to other thnicities. This study will provide this missing knowledge using a unique multi-ethnic Israeli population of Jews and Arabs that have one of the highest and lowest age-standardized incidence rates of CLL in the world, respectively, and characterized with different genetic backgrounds.

Enrollment: 1,500 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Individuals over the age pf 40

Exclusion criteria

• Individuals with lymphoproliferative disorder

Trial design

1,500 participants in 1 patient group

Clalit Health Services

Description:

Individuals over the age of 40 attending to the Clalit HMO clinics in the North of Israel for regular blood tests.