Risk-based Screen and Prognostic Analysis for Second Primary Malignancies in Kidney Cancer Patients

Peking University

Status

Completed

Conditions

Kidney Cancer

Treatments

Procedure: Surgery, radiation therapy and chemotherapy

Study type

Observational

Funder types

Other

Identifiers

NCT06531629

2024#07-03

Details and patient eligibility

About

Second primary malignancy (SPM) significantly impacts the survival and prognosis of patients. This study endeavors to identify risk and prognostic factors associated with SPM after first primary kidney cancer and construct predictive nomograms.

Full description

In recent years, with the advancement of cancer treatment techniques and the prolonged survival of patients, the prevalence of Second primary malignancy (SPM) has been escalating, emerging as a significant health issue among cancer survivors. The goal of this study is to identify risk and prognostic factors associated with SPM after first primary kidney cancer and construct nomograms to provide clinical evidence. The main questions this study aims to answer are: (1) What are the risk factors associated with the prevalence of SPM after kidney cancer? (2) What are the prognostic factors associated with the overall survival (OS) of kidney cancer patients with SPM? (3) How to accurately predict the probability of developing SPM after kidney cancer and the OS of kidney cancer patients with SPM? In this retrospective population-based cohort study, Patients diagnosed with first primary kidney cancer between 2000 and 2020 were retrospectively enrolled from the Surveillance, Epidemiology, and End Results (SEER) database. Researchers will concentrate on the risk and prognostic factors of SPM after kidney cancer, and develop nomograms to forecast the development and overall survival (OS) of SPM after kidney cancer.

Enrollment

72,408 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

(1) Diagnosed age was between 18 and 80 years old
(2) Diagnosed histologically confirmed as first primary kidney cancer
(3) The staging of kidney cancer was early or localized advanced (T1/2/3N0M0)
(4) Detailed survival data and follow-up information should be provided

Exclusion criteria

(1) Histological conformation for diagnosis was unavailable
(2) The type of reporting source was "Death certificate only" or "Autopsy only"
(3) Patients with other malignancies before the diagnosis of primary kidney cancer
(4) The staging of kidney cancer was not early or localized advanced (T1/2/3N0M0)
(5) Diagnosis interval between first primary malignancy (FPM) and second primary malignancy (SPM) was less than 6 months
(6) The information was not complete