Risk Factors and A Prediction Model of Recurrence of Uterine Fibroids

W

Wenwen Wang

Status

Not yet enrolling

Conditions

Uterine Fibroid
Recurrence

Treatments

Other: No intervertion

Study type

Observational

Funder types

Other

Identifiers

NCT06234670
V1.0

Details and patient eligibility

About

To research risk factors for recurrence of uterine fibroids and build a prediction model of recurrence of uterine fibroids to facilitate the early detection as well as the early intervention for patients who are prone to recur.

Full description

Uterine fibroids are the most common benign tumors of female reproductive organs during childbearing age. With the emphasis on fertility preservation and the pursuit of the physical integrity, about 46% of patients prefer the conservative surgery which preserves the uterus. However, the high recurrence rate of uterine fibroids after conservative surgery does cause formidable clinical problems. According to the literature, the recurrence rate is about 11.7% at one year after myomectomy and would increase steadily. At the eighth year of myomectomy, the recurrence rate is as high as 84.4%. During the long-term follow-up, about one-third of patients eventually require reoperation. Recurrence not only leads to the recurrence of fibroid-related symptoms such as anemia, abdominal and pelvic pain, frequent urination and urgency, abnormal stool, etc., but also increases the burden of economic and national medical insurance, besides, it even causes serious problems such as psychological disorders, infertility, adverse pregnancy outcomes and malignant transformation, which affecting physical and mental health as well as destroying family happiness and threatening national population security.

Enrollment

3,200 estimated patients

Sex

Female

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Age:18-50 years
  2. Diagnosed with uterine fibroids (by ultrasound or pathology)
  3. Accept myomectomy.
  4. Complete clinical data.

Exclusion criteria

  1. Severe infectious disease
  2. Previous history of malignant tumors
  3. Incomplete clinical data.
  4. Pregnant

Trial design

3,200 participants in 1 patient group

Patients with uterine fibroids accepted myomectomy.
Description:
Complete the observation and follow-up, to identify the outcome (recur or not recur).
Treatment:
Other: No intervertion

Trial contacts and locations

1

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Central trial contact

Wenwen Wang, Phd; shixuan Wang, Phd

Data sourced from clinicaltrials.gov

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