Risk Factors and Machine Learning Model for Aminoglycines Related Acute Kidney Injury

Qianfoshan Hospital

Status

Completed

Conditions

Acute Kidney Injury

Aminoglycoside Toxicity

Treatments

Drug: Aminoglycoside

Study type

Observational

Funder types

Other

Identifiers

NCT05533593

LCYY-LX-20220102

Details and patient eligibility

About

Drug-induced acute kidney injury (D-AKI) can occur after treatment with aminoglycosides. Predicting the risk of D-AKI is important for a tailored prevention and palliation strategy. There are currently no studies to construct a model for predicting the risk of D-AKI associated with aminoglycosides. Therefore, the study aimed to develop a model to predict the risk of D-AKI that could be used in clinical practice. Clinical data of inpatients treated with aminoglycosides at the First Affiliated Hospital of Shandong First Medical University from January 2018 to December 2020, were collected. The primary endpoint was D-AKI, defined according to the 2012 Global Outcomes for Kidney Disease Improvement (KDIGO). Patient clinical information, including demographic information, admission and discharge information, disease history, medication information, and laboratory tests, was obtained through an in-hospital electronic medical record system. Independent risk factors associated with D-AKI will be screened by univariate and multifactorial analyses. Covariates with significant differences (P < 0.05) were included in logistic regression models. The models were evaluated by the area under the curve (AUC) of the receiver operating characteristic curve (ROC) obtained by ten-fold cross-validation. Future studies are needed to test the application of this model in clinical practice to determine whether D-AKI in this setting can be predicted and mitigated.

Enrollment

8,000 patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All inpatients who used aminoglycosides during hospitalization
Hospital stay ≥ 48h
Age ≥18 years
There are two or more blood creatinine tests during hospitalization

Exclusion criteria

Hospital stay < 48h
Age <18 years
Glomerular filtration rate (GFR) < 30ml/min/1.73m2 within 48 hours after admission
AKI was diagnosed on admission
Less than two Scr test results during hospitalization
The Scr values were always lower than 40 μmol/L during hospitalization
Cases with incomplete medical history information