Risk Factors and Machine Learning Model for Proton Pump Inhibitor Related Acute Kidney Injury

Qianfoshan Hospital

Status

Completed

Conditions

Proton Pump Inhibitor

Acute Kidney Injury

Treatments

Drug: Proton pump inhibitor

Study type

Observational

Funder types

Other

Identifiers

NCT05533619

LCYY-LX-20220104

Details and patient eligibility

About

Recent evidence concerns acute kidney injury (AKI) following proton pump inhibitor (PPI) application. Few actual studies have compared the incidence, risk factors, and predictive models of AKI associated with PPI. The present study was a single-center retrospective study. The researchers retrospectively analyzed data from patients who received PPI medications between January 2018 and December 2020. PPI drugs included omeprazole, esomeprazole, rabeprazole, and pantoprazole. The primary outcome of the study was AKI, as defined by kidney disease: improving global outcomes (KDIGO). Secondary outcomes included length of hospital stay, hospital costs, and continuous renal replacement therapy. Independent risk factors associated with AKI were identified by univariate analysis and multifactorial logistic regression analysis (P < 0.05). Logistic regression models were constructed based on the variables obtained from the analysis. Internal validation of the model was performed by the ten-fold cross-validation method. Model discriminatory power was assessed by the area under the curve (AUC) of the receiver operating characteristic curve (ROC). The study aims to develop a PPI-related AKI prediction model based on an electronic medical record system that can be used to predict AKI in hospitalized patients and contribute to the early prevention, diagnosis and treatment of AKI, ultimately reducing morbidity and improving prognosis.

Enrollment

30,000 patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All inpatients who used proton pump inhibitor during hospitalization
Hospital stay ≥ 48h
Age ≥18 years
There are two or more blood creatinine tests during hospitalization

Exclusion criteria

Hospital stay < 48h
Age <18 years
Glomerular filtration rate (GFR)< 30ml/min/1.73m2 within 48 hours after admission
AKI was diagnosed on admission
Less than two Scr test results during hospitalization
The Scr values were always lower than 40 μmol/L during hospitalization
Cases with incomplete medical history information