Risk Factors and the Effect of Plasma Exchange on Prognosis of Pregnancy-related Thrombotic Microangiopathies

Peking University

Status: Unknown

Conditions: Pregnancy-related Thrombotic Microangiopathies

Treatments: Device: plasma exchange

Study type: Observational

Funder types: Other

Identifiers

NCT04949698

LM2020304

Details and patient eligibility

About

Early identification of the risk factors of pregnancy-related thrombotic microangiopathies can help us reduce the complications of such patients and increase the survival rate of patients. In addition, it is still controversial whether patients with pregnancy-related thrombotic microvessels should receive plasma therapy.

Full description

"Objective: To evaluate the risk factors of pregnancy-related thrombotic microangiopathies and the effect of plasma exchange on the prognosis (recovery status of renal function, recovery status of platelets, survival or death within 28 days).

Design: A retrospective analysis of pregnant patients admitted to the ICU from 2015 to 2019. According to the outcome indicator of the occurrence of pregnancy-related thrombotic microangiopathies, they were divided into thrombotic microangiopathies group and non-thrombotic microangiopathies group. Patients in the pregnancy-related thrombotic microangiopathy group were divided into plasma exchange combined non-plasma exchange group according to whether they received plasma exchange. Collect the clinical data of the patients, and analyze the data using SPSS 1 7.0 statistical software package. The measurement data were compared by paired t test and one-way analysis of variance; the count data were compared by χ2 test. Compare the differences of the indicators between the two groups and analyze the risk factors of pregnancy-related thrombotic microangiopathies. Then compare whether there is a difference in the prognosis between the plasma exchange group and the non-plasma exchange group."

Enrollment: 50 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pregnant patients admitted to the Department of critical care medicine, the Third Hospital of Peking University from 2015 to 2019

Exclusion criteria

• NO

Trial design

50 participants in 3 patient groups

No TMA

Description:

parturients without thrombotic microangiopathies

Treatment:

Device: plasma exchange

TMA with plasma exchange

Description:

parturients with thrombotic microangiopathies, and treated with plasma exchange

Treatment:

Device: plasma exchange

TMA without plasma exchange

Description:

parturients with thrombotic microangiopathies, but not treated with plasma exchange

Treatment:

Device: plasma exchange