Risk Factors Associated With Infection After Spine Surgery

Capital Medical University

Status: Completed

Conditions: Spine Surgery; Deep Surgical Site Infection

Treatments: Procedure: open posterior instrumented thoracolumbar surgery

Study type: Observational

Funder types: Other

Identifiers

NCT05740865

Neurospine_infection

Details and patient eligibility

About

Surgical site infection (SSI), particularly deep SSI, is one of the most serious complications after spinal surgery. evaluating the risk of SSI and, correspondingly, prescription of prophylactic measures are extremely important to prevent SSI and avoid potentially devastating consequences. A retrospective study was conducted aiming to develop a point-based prediction model of deep surgical site infection in patients receiving open posterior instrumented thoracolumbar surgery.

Full description

Data of 3,419 patients in 4 hospitals from Jan 1, 2012 to Dec 30, 2021 were retrospectively collected and were evaluated aiming to develop a point-based prediction model of deep surgical site infection in patients receiving open posterior instrumented thoracolumbar surgery. Clinical knowledge-driven, data-driven and decision tree model was used to identify predictive variables of deep SSI. Internal validation was performed by using bootstrapping methods.

Enrollment: 3,419 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

patients who previously received open posterior instrumented thoracolumbar surgery

Exclusion criteria

1. were aged < 18 years;
2. underwent surgery for the spinal infection, spine revision surgery, or cervical operation;
3. were diagnosed as superficial SSI;
4. died in hospital;
5. diagnosis of SSI was not determined;
6. had missing data more than 10% were excluded.

Trial design

3,419 participants in 2 patient groups

patients who developed deep surgical site infection after thoracolumbar surgery

Description:

this group included patients who developed deep surgical site infection after open posterior instrumented thoracolumbar surgery

Treatment:

Procedure: open posterior instrumented thoracolumbar surgery

patients who did not develop deep surgical site infection after thoracolumbar surgery

Description:

this group included patients who did not develop deep surgical site infection after open posterior instrumented thoracolumbar surgery

Treatment:

Procedure: open posterior instrumented thoracolumbar surgery