Risk Factors for Acute Kidney Injury in Critically Ill Patients With Acute-on-Chronic Liver Failure

Institutul Clinic Fundeni

Status: Enrolling

Conditions: Acute-On-Chronic Liver Failure; Acute Kidney Injury

Study type: Observational

Funder types: Other

Identifiers

NCT04525625

AKI-ACLF

Details and patient eligibility

About

Acute kidney injury (AKI) is one of the most important factors associated with increased mortality in patients with acute-on-chronic liver failure (AoCLF). Early identification and treatment of this subgroup of patients may improve survival and decrease ICU length of stay. As kidney ischemia is one of the main mechanisms responsible for AKI in AoCLF, an increase in urinary to arterial partial pressure of oxygen may help in the early diagnosis of renal failure. For this arterial and urinary oxygen pressure will be measured at ICU admission, on day 1 and day 3 of ICU stay. Diagnosis of AKI within the first 28 days after ICU admission will be recorded

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients admitted to the ICU for acute-on-chronic liver failure

Exclusion criteria

• pre-existing renal disease
• urine output<200 mL/day
• death within the first 24 hours after ICU admission
• emergency liver transplantation within the follow-up period (28 days)