Risk Factors for AD-Associated Switch to Mania

Hospital Clinic of Barcelona

Status: Completed

Conditions: Bipolar Disorder

Treatments: Drug: Selective Serotonin Reuptake Inhibitors (SSRI), Serotonin-Norepinephrine Reuptake Inhibitor( SNRI), and Tricyclics.

Study type: Observational

Funder types: Other

Identifiers

NCT01503489

SWITCH.

Details and patient eligibility

About

The present study aimed at identifying clinical risk factors for switch into (hypo)mania or mixed states, within 8 weeks after introduction of an antidepressant or after increasing its dosage.

Full description

Treatment of bipolar depression with antidepressants is strongly debated for the methodologically poor and insufficient data supporting their use and the widely held belief that antidepressants can induce new episodes of abnormal mood elevation or accelerate the rate of cycling. The present study aimed at identifying clinical risk factors for switch into (hypo)mania or mixed states, within 8 weeks after introduction of an antidepressant or after increasing its dosage, in a prospective, longitudinal design.

Enrollment: 221 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Bipolar I and II disorder.

Exclusion criteria

• Major medical comorbidities.

Trial design

221 participants in 1 patient group

Bipolar depressed patients

Description:

Bipolar I or II outpatients, current major depressive episode (HDRS-17 over 20).

Treatment:

Drug: Selective Serotonin Reuptake Inhibitors (SSRI), Serotonin-Norepinephrine Reuptake Inhibitor( SNRI), and Tricyclics.