Risk Factors for Catheter-Related Bloodstream Infections in Hospitalized Intestinal Failure Patients

Jinling Hospital, China

Status: Completed

Conditions: Intestinal Failure; Catheter-related Bloodstream Infection

Study type: Observational

Funder types: Other

Identifiers

NCT07172711

20250901

Details and patient eligibility

About

This retrospective cohort study aims to identify risk factors for catheter-related bloodstream infections (CRBSIs) in hospitalized patients with intestinal failure (IF), including all subtypes (Types I-III). The study included 321 patients with 9,365 catheter-days. Multivariate logistic and Cox regression analyses were used to identify independent risk factors. Stratified analyses identified subtype-specific risks, and hospital stay length and health economic outcomes were assessed. The study highlights the need for subtype-tailored prevention strategies and closer metabolic and immune monitoring in hospitalized IF patients.

Enrollment: 321 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients meeting the ESPEN 2023 diagnostic criteria for intestinal failure.

Exclusion criteria

• Catheter indwelling duration <48 hours; Implanted catheter before admission; Complex components in PN difficult to quantify; Positive blood cultures with unclear CRBSI diagnosis; Alternative infection sources identified.

Trial design

321 participants in 2 patient groups

CRBSIs

Description:

Patients with intestinal failure who developed catheter-related bloodstream infection

Non-CRBSI

Description:

Patients with intestinal failure who never developed catheter-related bloodstream infection