Risk Factors for Chronic Postoperative Pain After Elective Nephrectomy

Istanbul University - Cerrahpasa (IUC)

Status: Not yet enrolling

Conditions: Epidural Analgesia; Surgery; General Anesthesia; Analgesic Drugs; Chronic Pain; Nephrectomy; Acute Pain, Postoperative; Chronic Pain, Postoperative; Anesthesia

Treatments: Diagnostic Test: Numeric Rating Scale

Study type: Observational

Funder types: Other

Identifiers

NCT06673979

E-83045809-604.01-1084787

Details and patient eligibility

About

Chronic postoperative pain (CPP) is typically defined as pain persisting for 3 months or more after surgery[1]. CPP is a common and increasingly prevalent morbidity, leading to long-term psychological issues, reduced quality of life, and impaired functionality[2]. To reduce the incidence of CPP, high-risk patients are identified, and various surgical techniques, pharmacological agents, and regional anesthesia techniques are employed[3].

The primary aim of our study is to scale chronic pain at 1 hour, 3 months, and 1 year post-nephrectomy using the Numeric Rating Scale (NRS), ranging from 0 to 10. The secondary aim is to evaluate the effects of factors influencing chronic postoperative pain on the NRS scores.

Full description

Patients gender, age, height(m), weight(kg), body mass index(kg/m2), diagnosis, smoking and alcohol history, comorbidities, surgical technique and duration, complications, lymph node dissection, thrombectomy, adrenalectomy, amount of bleeding(cc), need for blood transfusion, need for intensive care, analgesia technique used, amount of opioids and non-opioid analgesics used perioperatively, amount of vasopressors used, heart rate(bpm) and mean arterial pressure(mmHg) at induction, post-intubation, post-extubation, and 1 hour postoperatively, presence of postoperative pain, chronic analgesic use history(more than 3 uses per week), presence of fibromyalgia, frequent urinary tract infections, diagnosed with central sensitization disorders, bruxism, depression-panic attacks, allergic asthma, irritable bowel syndrome, and migraines will be recorded. The effects of these factors on NRS scores at 1 hour, 3 months, and 1 year postoperatively will be examined.

Enrollment: 220 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: -Patients aged 18-90 years,

• ASA I-IV,
• undergoing elective nephrectomy under general anesthesia will be included in the study.

Exclusion Criteria:

• Patients who cannot be reached by phone and hose who die within the 1-year postoperative period will be excluded from the study.

Trial design

220 participants in 2 patient groups

Painfull: patients with Numeric Rating Score equal or higher than 4

Description:

The patients are asked to rate their pain according to the Numeric Rating Scale (0=no pain; 10=worse possible pain), and patients with NRS equal or higher than 4 are defined as "painfull".

Treatment:

Diagnostic Test: Numeric Rating Scale

Pain-free: patients with Numeric Rating Score lower than 4

Description:

The patients are asked to rate their pain according to the Numeric Rating Scale (0=no pain; 10=worse possible pain), and patients with NRS lower than 4 are defined as "pain-free".

Treatment:

Diagnostic Test: Numeric Rating Scale