Risk Factors for Microvascular Obstruction Post-Emergency PCI in AMI Patients

Central South University

Status

Enrolling

Conditions

Acute Myocardial Infarction (AMI)

Study type

Observational

Funder types

Other

Identifiers

NCT07042321

cy25231

Details and patient eligibility

About

The goal of this prospective cohort study is to investigate the relationship between the TyG index and early identification of MVO in AMI patients undergoing emergency PCI and CMR imaging. The study will enroll approximately 300 AMI patients treated at Xiangya Third Hospital of Central South University from June 2024 to August 2025. The main questions it aims to answer are:

How does the TyG index correlate with the early detection of MVO?
What differences in cardiovascular adverse events during hospitalization exist between groups with varying TyG index levels? Participants will undergo emergency PCI and CMR imaging within 3-7 days post-procedure. Data collected will include demographic characteristics, clinical history, coronary angiography data, laboratory test indicators (especially metabolic markers such as blood glucose and lipids), IVUS-related plaque information, and CMR results.

Enrollment

300 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥ 18 years.
STEMI symptom onset time < 12 hours.
STEMI symptom onset time 12-48 hours, with ongoing ischemic symptoms, hemodynamic instability, or life-threatening ventricular arrhythmias.
Very high-risk NSTEMI; undergoing emergency PCI treatment.
Voluntary signed informed consent form.

Exclusion criteria

Non-obstructive acute myocardial infarction.
Severe chronic kidney disease (defined as estimated glomerular filtration rate <20 mL/min per 1.73 m²).
Pregnant women or those planning to become pregnant.
Failure of emergency PCI.
Unclear CMR images