Risk Factors for Non-response to Hormonal Medical Therapy in Patients With Endometriosis

Scientific Institute for Research Hospitalization and Healthcare (IRCCS)

Status

Enrolling

Conditions

Endometriosis

Study type

Observational

Funder types

Other

Identifiers

NCT06413381

ENDOFAIL - 01

Details and patient eligibility

About

Determine the proportion of patients with endometriosis unresponsive to medical therapy and to compare the clinical and ultrasonographic characteristics of this group of patients (study group) with the clinical and ultrasonographic characteristics of patients responsive to medical therapy (control group).

Enrollment

250 estimated patients

Sex

Female

Ages

18 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age between 18 and 50 years;
patients with endometriosis-related pain symptoms (dyspareunia, dyschezia, dysmenorrhea, chronic pelvic pain, dysuria, periovulatory pain, with at least one of these symptoms presenting Numerical Pain Rating Scale intensity > 5);
indication for administration of oral hormonal medical treatment for endometriosis;
acquisition of informed consent.

Exclusion criteria

patients with contraindications to oral hormone treatment
current or previous pelvic infections
history of malignancy or current suspicion of gynecologic malignant lesions
previous pelvic surgery (hysterectomy, salpingectomy, ovarian cyst removal, myomectomy, surgery for endometriosis, bowel resections)
positive history of other causes of chronic pelvic pain
post-menopausal status