Risk Factors for Piperacillin/Tazobactam Resistance in Extended-Spectrum Beta-Lactamase (ESBL) Producing Organisms

University of Pittsburgh

Status: Completed

Conditions: Enterobacteriaceae Infections

Study type: Observational

Funder types: Other

Identifiers

NCT00573521

PRO07100136

Details and patient eligibility

About

This research will be conducted to determine whether risk factors exist for piperacillin/tazobactam resistance in ESBL organisms.

Full description

This is chart review at UPMC. NO human subject interaction will occur.

Enrollment: 450 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical information is collected by chart review of "case" and "control" patients.
• A "case A" patient is defined as follows: One or more clinical cultures are positive for an ESBL producing bacteria and the organism is piperacillin/tazobactam resistant.
• A "case B" patient is defined as follows: One or more clinical cultures are positive for an ESBL producing bacteria and the organism is piperacillin/tazobactam susceptible.
• Additionally, 1 control patient in the hospital at the same time as the case patients will be randomly selected for each case and are not in either case group.

Exclusion criteria

• Patients < 18 years of age