Risk Factors for Quinolone Resistance Among ESBL Producing Klebsiella Species

University of Pittsburgh

Status: Completed

Conditions: Klebsiella Species; Infection; Quinolone Resistance; ESBL

Study type: Observational

Funder types: Other

Identifiers

NCT00518661

PRO07070356

investigator funding (Other Identifier)

Details and patient eligibility

About

This is a retrospective chart review. This proposed study aims to document the risk factors for quinolone resistance in bloodstream isolates of Klebsiella species. Additionally, the adequacy of empiric antibiotic therapy for Klebsiella bloodstream infections will be assessed.

Full description

This is a retrospective chart review. This proposed study aims to document the risk factors for quinolone resistance in bloodstream isolates of Klebsiella species. Additionally, the adequacy of empiric antibiotic therapy for Klebsiella bloodstream infections will be assessed. This research is (c) important because identification of risk factors may allow earlier initiation of appropriate therapy in patients infected with these bacteria. Additionally, we will identify whether horizontal spread is responsible for this increasing trend.

Enrollment: 500 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• must be quinolone resistant among ESBL producing klebsiella species

Exclusion criteria

• Those not meeting entry criteria