Risk Factors for Recurrent Urinary Tract Infection in Children

Kaunas University of Medicine

Status: Completed

Conditions: Urinary Tract Infection; Cystitis; Pyelonephritis

Study type: Observational

Funder types: Other

Identifiers

NCT00528476

BE-2-68

Details and patient eligibility

About

The purpose of this study is to determine clinical and urodynamic risk factors for recurrent urinary tract infection in 5-18 years old children.

Full description

It is known, that in the group of young children the most common reason of recurrent UTI is anatomic abnormalities, such as vesicoureteral reflux, hydronephrosis. However, not all recurrent UTI can be explained by anatomic abnormalities. The vast majority of school age children with recurrent UTI have anatomically normal urinary tract. Recent studies discuss about the role of behavioral and functional abnormalities (inadequate fluid intake, stool retention, infrequent voiding, etc.) that can predispose recurrent urinary tract infections. Influence of some these abnormalities for recurrent UTI is controversial. Family history, behavioral and functional abnormalities which predispose to urinary tract infections in children with normal urinary tract are neglected in most protocols of urinary tract infection.

Children in this study receive a careful evaluation including complete history, voiding-drinking diary, bowel questionnaire, physical investigation, sonography, voiding cystourethrogram.

Follow up time - 1 year. Urinalysis once a month and during each episode of fever.

Enrollment: 161 patients

Sex: All

Ages: 5 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 5-18 years old children, who were treated because of cystitis and pyelonephritis in Kaunas Medical University Hospital

Exclusion criteria

• urinary tract malformations
• neurogenic bladder dysfunction
• patients, who received immunosuppressive drugs
• pregnant girls
• children with non bacterial urinary tract infection

Trial design

161 participants in 2 patient groups

1

Description:

Patients, who were treated because of recurrent (2 or more urinary tract infections per year) pyelonephritis or cystitis.

2

Description:

Patients with nonrecurrent urinary tract infections (patients who had no history of more than one urinary tract infections in last year).