Risk Factors for Sub Mucosal Fibrosis During Achalasia Cardia: A Prospective Study

Asian Institute of Gastroenterology, India

Status: Enrolling

Conditions: Esophagus Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT06815341

SMF

Details and patient eligibility

About

Classification for Stasis Esophagitis:

Grade I Grade II Grade III Vascular pattern Obscured Obscured Obscured Mucosal thickening No Yes Yes Ulceration No Yes Yes Nodularity No No Yes

Full description

Predictors of Submucosal Fibrosis:

Various factors were analysed for prediction of SMF including age, gender, stasis esophagitis, type of achalasia, duration of disease, lower esophageal sphincter pressure (LESP), height of barium column on barium esophagogram and severity of symptoms (Eckardt score). Esophageal mucosa was graded for the severity of stasis esophagitis (grade I to grade III) based on vascular pattern, mucosal thickening, ulceration and nodularity. SMF was graded (I minimal, II moderate, III severe) according to mucosal lift, difficulty in entry, density of SM fibers, separation of mucosa and muscle.

Enrollment: 339 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients (between 18 to 75 years of age) who underwent POEM for achalasia or other esophageal motility disorders.
• Had a diagnosis of esophageal achalasia confirmed by High Resolution Manometry, barium esophagogram.

Exclusion criteria

• Patients who underwent treatment other than achalasia
• Lost to follow up patients.
• Incomplete clinical record patients
• Patients not willing to participate in the study