Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes

University College London (UCL)

Status: Completed

Conditions: Subarachnoid Hemorrhage; Ischemic Stroke; Unstable Angina; Transient Ischemic Attack; Cardiovascular Diseases; Heart Failure; Peripheral Arterial Disease; Cardiac Arrest; Ventricular Arrhythmia; Chronic Stable Angina; Cerebrovascular Accident; Abdominal Aortic Aneurysm; Sudden Coronary Death; Acute Myocardial Infarction; Heart Diseases; Sudden Death

Study type: Observational

Funder types: Other

Identifiers

NCT01804439

CALIBER 12_153R

Details and patient eligibility

About

Cardiovascular disease (CVD) is an important public health problem that affects millions of people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or hypertension, and prevalent CVD are well documented. However, few studies have investigated associations with onset of disease. The initial manifestation of CVD, for example an episode of unstable angina, is important because it influences the prognosis, the quality of life and the management of disease. Furthermore, the extent to which social deprivation, alcohol consumption or atrial fibrillation affects presentation of CVD is poorly understood and deserves further consideration.

Most previous studies have considered CVD as a single entity. However, differences in aetiology between coronary phenotypes suggest that risk factors may not be shared across specific coronary phenotypes and their relative importance is likely to differ for each phenotype. Gaining knowledge of these differences could provide insights into the pathophysiology of specific forms of CVD and could eventually lead to modification of recommendations for patient management and disease prevention.

We propose to use the linkage of the national registry of coronary events to general practice records in the Clinical Practice Research Database (CPRD), to investigate whether demographic, behavioral, and clinico-metabolic risk factors differentially influence the onset of specific types of CVD.

Enrollment: 2,240,000 patients

Sex: All

Ages: 30+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged ≥30yrs old
• Registered in CPRD practices in England consenting to data linkage
• ≥1 year of up-to-standard pre-study follow-up

Exclusion criteria

• History of any of the CVD endpoints considered before study follow-up initiation.

Trial design

2,240,000 participants in 1 patient group

CALIBER Healthy Cohort

Description:

We will report findings from the CALIBER (CArdiovascular disease research using Linked BEspoke studies and Electronic Records) collaboration where we linked primary care data (from the General Practice Research Database \[GPRD\]) to three further sources of electronic health records: the Myocardial Ischemia National Audit Project registry (MINAP),cause specific discharge data from Hospital Episodes Statistics (HES) and cause specific mortality from the Office for National Statistics (ONS).