Risk Factors of Failure of Conservative Treatment in Acute Non Complicated Appendicitis (appendicitis)

Ahmed Mohammed Hussein Sayed

Status: Not yet enrolling

Conditions: Conservative Management

Treatments: Drug: ceftriaxone; Drug: ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly

Study type: Observational

Funder types: Other

Identifiers

NCT06828952

acute appendicitis

Details and patient eligibility

About

From this study, it can be concluded that patients who meet the following criteria are more likely to fail expectant management and thus should not be considered for the NOM of uncomplicated acute appendicitis. These include the duration of symptoms before presenting to a surgical emergency , the presence of fever within 24 hours of presenting to a surgical emergency, TLC cells/dL, CRP mg/L, appendix diameter mm, modified Alvarado score , and adult appendicitis score .

Full description

Expectant management with intravenous antibiotic therapy alone has emerged as an effective alternative to appendectomy for the treatment of uncomplicated acute appendicitis . It is important to identify patients at the onset of the disease who are likely to have successful outcomes for conservative management.

Enrollment: 100 estimated patients

Sex: All

Ages: 16 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male or female patients é diagnosis of acute appendicitis .
• Patients with ages: from 16 to 60 years old.

Exclusion criteria

• complicated AA (appendicolith, perforation, peri appendicular abscess or suspicion of a tumor).
• inflammatory bowel disease.
• inability to co-operate and give informed consent.
• diffuse peritonitis.
• antibiotic documented allergy & allergy to contrast media .
• Patients with serious comorbid conditions DM & renal insufficiency, serum creatinine > 150 μmol/l .
• Pregnant & lactating patient.
• Patients with bleeding diathesis and those on anticoagulants.
• Patients with advanced malignancies & patient on immunosuppressive drugs .
• Patients with previous appendectomy.
• Extreme of age.

Trial design

100 participants in 1 patient group

(1) Male or female patients é diagnosis of acute appendicitis.

Description:

Patients who presented with complaints of right lower quadrant pain with symptoms and signs strongly suggestive of uncomplicated acute appendicitis that was confirmed on ultrasonography, were included. The modified Alvarado score and adult appendicitis score were calculated.

Treatment:

Drug: ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly

Drug: ceftriaxone