Risk Factors of Medistinal Metastasis in Endoscopic Staging of Lung Cancer

National Cancer Center (NCC)

Status: Active, not recruiting

Conditions: Non Small Cell Lung Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT02991924

NCC2016-0156

Details and patient eligibility

About

The purpose of this study is to investigate risk factors for mediastinal lymph node metastasis in potentially operable non-small cell lung cancer in order to find indications for endoscopic mediastinal staging. Chest CT, integrated PET/CT, and endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) +/- endoscopic ultrasound with bronchoscope-guided fine needle aspiration (EUS-B-FNA) are performed for mediastinal staging. CT and PET/CT findings, histologic types and other risk factors will be analyzed. The investigators develop the prediction method for mediastinal metastasis.

Enrollment: 600 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically confirmed or strongly suspected non-small cell lung cancer (NSCLC)
• Potentially operable

Exclusion criteria

• M1 disease
• Inoperable T4 disease
• Mediastinal infiltration or extranodal invasion of the mediastinal lymph node visible on chest CT
• Confirmed supraclavicular lymph node metastasis
• Pancoast tumours
• T1 ground glass opacity nodule (with solid part 1<cm)
• Solid T1 (1<cm)N0 M0 by CT & PET/CT
• Inoperable patients (after evaluating medical and surgical operability)
• Patients who refused surgical treatment
• Contraindications for bronchoscopy
• Drug reaction to lidocaine, midazolam, fentanyl
• Pregnancy