Risk Factors of Perforated HSCR in Neonates

Tongji Hospital

Status: Completed

Conditions: Hirschsprung Disease; Bowel; Perforation, Fetus or Newborn

Treatments: Procedure: Emergency surgical enterostomy

Study type: Observational

Funder types: Other

Identifiers

NCT05044741

Perforated HSCR

Details and patient eligibility

About

Hirschsprung's disease (HSCR) is a common digestive malformation with radiographic evidence of distal bowel obstruction and clinical signs of abdominal distension, vomiting, constipation, and failure to pass meconium. Bowel perforation (perforated HSCR) is a very serious complication of HSCR, but if this occurs it is most often in the neonatal period. The current study collected information on all cases diagnosed with perforated HSCR from multi-centers in China over 10 years, the aim was to evaluate the clinical features of perforated HSCR, and investigate possible risk factors for perforated HSCR in neonates.

Enrollment: 600 patients

Sex: All

Ages: Under 30 days old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Neonates (≤1 month age)
• Diagnosed with HSCR
• Suffered with bowel perforation

Exclusion criteria

• Patients complicated with suspected necrotizing enterocolitis (NEC), imperforate anus (IA), intestinal atresia, and meconium plug syndrome
• Neonates who transferred from outside participating hospitals.

Trial design

600 participants in 2 patient groups

Perforated group

Treatment:

Procedure: Emergency surgical enterostomy

Controlled group