Risk Factors of Spontaneous Fungal Peritonitis in Cirrhotic Patients

Sohag University

Status: Completed

Conditions: Spontanous Fungal Peritonitis

Treatments: Diagnostic Test: ASCITIC FLUID CULTURE

Study type: Observational

Funder types: Other

Identifiers

NCT05117073

Soh-Med-21-10-53

Details and patient eligibility

About

Spontaneous bacterial peritonitis (SBP) is an infection of the peritoneal cavity with no surgically treatable intra-abdominal source of infection. Spontaneous peritonitis is a potentially fatal complication in patients with advanced liver cirrhosis. It is estimated that 10-20 % of patients with cirrhotic ascites may develop spontaneous peritonitis, which is usually caused by a bacterial infection.

In contrast, spontaneous fungal peritonitis (SFP) is less well-recognized. SFP may be associated with higher mortality rates than SBP but therapeutic approaches are largely undefined. To this end, the epidemiology and outcomes of patients with SFP have only been documented sporadically aimed to evaluate the risk factors for the development of spontaneous fungal peritonitis (SFP), and the prognosis of SFP compared with SBP

Full description

Cross-sectional study

Studied population & locality:

Patients with signs and symptoms suggestive of spontaneous peritonitis who will be admitted to Tropical medicine and Gastroenterology or Internal medicine departments in Sohag university hospitals during the period from september 2021 to december 2022 will be included in the study.

According to the results of ascitic fluid analysis, we will divide the patients into 2 groups:

Group (1): patients with spontaneous bacterial peritonitis (SBP). Group (2): patients with spontaneous fungal peritonitis (SFP).

Exclusion criteria:

Patients seropositive for human immunodeficiency virus (HIV) and patients undergoing continuous ambulatory peritoneal dialysis were excluded from this study.

Methods:

All included patients will be subjected to:

1. Detailed history, complete general and systemic examination.
2. Ascitic fluid analysis
3. Bacterial and fungal culture from ascitic fluid:
4. Laboratory investigations:

Fasting blood sugar Liver function tests. CBC.

Ethical considerations:

Enrollment: 100 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients with signs and symptoms suggestive of spontaneous peritonitis who will be admitted to Tropical medicine and Gastroenterology or Internal medicine departments in Sohag university hospitals during the period from September 2021 to december 2022

Exclusion criteria

Patients seropositive for human immunodeficiency virus (HIV) and patients undergoing continuous ambulatory peritoneal dialysis were excluded from this study.

Trial design

100 participants in 2 patient groups

spontaneous bacterial peritonitis

Description:

cirrhotic patients diagnosed with SBP

Treatment:

Diagnostic Test: ASCITIC FLUID CULTURE

spontaneous fungal peritonitis

Description:

irrhotic patients diagnosed with SFP

Treatment:

Diagnostic Test: ASCITIC FLUID CULTURE