Risk Markers of Arterial Aging. The Paris Prospective Study III-2 (PPS3-2)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Not yet enrolling

Conditions: Arterial Stiffness

Treatments: Other: high-precision carotid echo-tracking

Study type: Observational

Funder types: Other

Identifiers

NCT06079424

C21-67

Details and patient eligibility

About

The main objectives of PPS3-2 are (i) to describe the dynamics of vascular aging and baroreflex sensitivity 12 to 16 years a part, (ii) to identify their determinants, and (iii) to quantify the subsequent risk of cardiovascular diseases.

Full description

Since May 2008, PPS3 is being following the CVD morbidity of 10157 healthy volunteers aged 50-75 years at baseline. In PPS3-2, we plan to re-invite survivors and volunteers of PPS3 to undergo a second physical examination. In particular, they will undergo a second high-precision carotid echotracking to measure vascular aging parameters and baroreflex sensitivity, permitting to study their respective dynamics. They will also underwent for the first time ultra fast echo of the radial artery to measure vascular aging parameters of the medium-sized arteries. According to fundings, blood samples will be taken and stored at -80°C in the whole population or in a subsample.

Enrollment: 7,500 estimated patients

Sex: All

Ages: 60 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being enrolled in PPS3 and having signed an informed consent for PPS3-2

Exclusion criteria

• Institutionalized participants
• Participants under guardianship
• Participants under judicial safeguard measure

Trial design

7,500 participants in 1 patient group

Level of vascular aging

Description:

community-based prospective longitudinal cohort

Treatment:

Other: high-precision carotid echo-tracking