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Risk of Aspergillus Infection in Patients With Chronic Lung Disease

L

Lin Chen

Status

Completed

Conditions

Fungal Infection Lungs

Treatments

Other: No intervention

Study type

Observational

Funder types

Other

Identifiers

NCT06379568
SichuanPPHLC01

Details and patient eligibility

About

Large doses of systemic corticosteroids ,severe lung tissue damage and longer COPD diagnosis may increase the risk of IPA in patients with chronic structural lung disease. By comparing the risk factors of aspergillus colonization group and aspergillus infection group, the main risk factors of aspergillus pneumonia were determined.

Full description

Patients with chronic lung disease were identified as positive for Aspergillus fumigatus through sputum microscopy. According to diagnostic criteria, patients diagnosed with IPA and CPA and were assigned to the Aspergillosis pneumonia group, while the remaining patients were included in the Aspergillus colonization group. Then,Risk factors for aspergillus pneumonia, invasive pulmonary aspergillus disease, and chronic pulmonary aspergillus disease, such as the use of high-dose corticosteroids, inhaled corticosteroids, and the extent of damage to basic lung structures, were identified by comparing the aspergillus colonization group with the aspergillus infection group.

Enrollment

209 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Age : at least 18 years old ;
  2. Imageological examination : Patients who complete high-resolution computed tomography (HRCT) images of the chest;
  3. Serological examination : Patients who complete serological test results, including serum aspergillus specific IgG antibody, serum aspergillus IgM antibody and GM antigen detection.

Exclusion criteria

  1. immunodeficiency conditions : Patients diagnosed with HIV infection, hematological malignancies, and autoimmune diseases.
  2. Critically ill patients : Those who require mechanical ventilation in the ICU and have established various types of cardiopulmonary bypass.
  3. Inadequate Clinical Data: Inability to provide reliable diagnostic measurements or insufficient clinical information.

Trial design

209 participants in 2 patient groups

Aspergillus pneumonia group
Description:
According to diagnostic criteria , patients diagnosed with IPA and CPA and were assigned to the Aspergillosis pneumonia group
Treatment:
Other: No intervention
control group
Description:
The remaining patients without IPA and CPA were included in the Aspergillus colonization group
Treatment:
Other: No intervention

Trial documents
2

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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