Risk of Diabetes in Young Turner Syndrome Patients

Cincinnati Children's Hospital Medical Center

Status: Completed

Conditions: Turner Syndrome

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT02160717

CCHMC-906

UL1TR000077 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Turner Syndrome is a common genetic disorder. Seventy percent of adults with Turner Syndrome have abnormalities in glucose metabolism which can lead to diabetes. The current screening guidelines for diabetes in Turner Syndrome are not specific and involve a fasting blood sugar once a year. The objective of this study is to determine if there are abnormalities in glucose metabolism and pancreatic function in young girls with Turner Syndrome. The study hypothesis is that pancreatic dysfunction (specifically of the beta cells that make insulin) is more prevalent in girls with Turner Syndrome compared to healthy controls.

Full description

The study will be conducted at Children's Hospital Medical Center, Cincinnati. The study will require 1 visit to the hospital where the subject will have an oral glucose tolerance test and a physical exam

Enrollment: 120 patients

Sex: Female

Ages: 6 to 22 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Turner Syndrome Females:

Inclusion Criteria:

• Turner Syndrome confirmed by chromosomal testing
• On standard therapy (growth hormone and or estrogen)

Exclusion Criteria:

• Type 1 or Type 2 diabetes
• Polycystic Ovarian Syndrome
• Pregnancy
• On any medications that alter blood sugar

Healthy Female Controls:

Inclusion Criteria:

• Healthy

Exclusion Criteria:

• Type 1 or Type 2 diabetes
• Polycystic Ovarian Syndrome
• Pregnancy
• On any medications that alter blood sugar

Trial design

120 participants in 2 patient groups

Turner Syndrome

Description:

Female with Turner Syndrome

Healthy Controls

Description:

Healthy Female