Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

IVI Vigo

Status: Completed

Conditions: Ectopic Pregnancy

Treatments: Other: Analysis of Ectopic Pregnancy incidence

Study type: Observational

Funder types: Other

Identifiers

NCT02793089

1409-VGO-059-EM

Details and patient eligibility

About

This study evaluates the increased risk of ectopic pregnancy associated with marked variation of estradiol during the early luteal phase and high progesterone on hCG day in IVF.

Full description

This is a retrospective cohort study of 578 patients who had no risk of EP (672 fresh transfer IVF cycles) between January 2005 and December 2014. Few studies have reported the relation between hormonal levels and ectopic pregnancy (EP) in IVF. Investigators describe EP incidence according to estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7) or their variation between both days.

Enrollment: 578 patients

Sex: Female

Ages: 25 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Normal Fallopian tubes in HSG and /or laparoscopy
• Normal Uterus: Abscence of myomas and Müllerian anomalies .

Exclusion criteria

• Previous Ectopic Pregnancy .
• Recurrent Abortion .
• Tubal Factor : pelvic inflammatory disease, Hydrosalpinx
• Previous abdominal surgery (except laparoscopy) .
• Prior Peritonitis
• Smoking (at least 1 cigarette/day) .

Trial design

578 participants in 4 patient groups

First quartile

Description:

No drugs are administered. It is an observational study. Collect retrospectively data.Analysis of Ectopic Pregnancy incidence through Estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7).

Treatment:

Other: Analysis of Ectopic Pregnancy incidence

Second quartile

Description:

No drugs are administered. It is an observational study. Collect retrospectively data.Analysis of Ectopic Pregnancy incidence through Estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7).

Treatment:

Other: Analysis of Ectopic Pregnancy incidence

Third quartile

Description:

No drugs are administered. It is an observational study. Collect retrospectively data.Analysis of Ectopic Pregnancy incidence through Estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7)

Treatment:

Other: Analysis of Ectopic Pregnancy incidence

Fourth quartile

Description:

No drugs are administered. It is an observational study. Collect retrospectively data.Analysis of Ectopic Pregnancy incidence through Estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7)

Treatment:

Other: Analysis of Ectopic Pregnancy incidence