Risk of Metabolic Adaptation After Weight Loss

Medical College of Wisconsin

Status: Enrolling

Conditions: Weight Loss; Obesity

Treatments: Other: lifestyle intervention with meal replacement program

Study type: Interventional

Funder types: Other

Identifiers

NCT05139420

PRO00039217

Details and patient eligibility

About

This study aims at identifying the neurohormonal biomarkers that characterize individuals at risk of greater metabolic adaptation to weight loss, a disproportionate decline in resting metabolic rate during and after weight loss.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

BMI > or = 30 any ethnicity

Exclusion criteria

weight > or = 400 lbs.

diabetes (type 2 or type 1)

hypertension

heart disease

kidney disease

liver disease

active cancer

post solid organ or bone marrow transplant

HIV/AIDS

pregnancy

breastfeeding

current smoker

current recreational drug use

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

lifestyle intervention

Experimental group

Description:

Participants will be enrolled in a weight loss program based on lifestyle changes. They will be given a 6-month subscription to a calorie-reduced meal replacement program that also offers lifestyle coaching.

Treatment:

Other: lifestyle intervention with meal replacement program