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Risk of Recurrence of Cervical Artery Dissection During Pregnancy and Puerperium

N

Nantes University Hospital (NUH)

Status

Completed

Conditions

Cervical Artery Dissection

Treatments

Other: questionnaries

Study type

Observational

Funder types

Other

Identifiers

NCT04253535
RC19_0267

Details and patient eligibility

About

Cervical artery dissection (CAD) accounts for about 2% of all strokes, and is a major cause of stroke in young people (about 15%). Many cases of CAD during pregnancy and puerperium have been described, suggesting that pregnancy and puerperium may be potential risk factors for CAD. The purpose of this study is to determine whether pregnancy and puerperium are also recurrence risk factors for CAD.

Full description

In this study, all women of childbearing age who had had a CAD between 2005 and 2017 are selected. Women are identified using the ICD10 diagnostic coding system. In addition, a text search with key words ("cervical or carotid or vertebral dissection") has been created in a data warehouse of the University Hospital of Nantes.

To determine the recurrence of CAD during pregnancy and puerperium, the participating women will be asked to answer to a questionnaire, by phone or mail. The questionnaire will be conducted by the same investigator, an experienced neurologist. Information about recurrence of CAD, number of pregnancies before and after the event will be recorded, as well as, the site of obstetrical monitoring, way of delivery, and management of antithrombotics, in case of further pregnancy. In case of no further pregnancy after the dissection, the reason will be explored.

Enrollment

91 patients

Sex

Female

Ages

18 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Extracranial carotid or vertebral dissection
  • Symptomatic dissection (with symptom onset within the last four weeks)
  • Spontaneous dissection
  • Imaging evidence of dissection on MRI/MRA, CTA or ultrasound.

Exclusion criteria

  • Minors or adults under guardianship
  • Intracranial artery dissection
  • Traumatic or iatrogenic dissection
  • Patient refusal to participate

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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