Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics

Duke University

Status: Withdrawn

Conditions: Posttraumatic Stress Disorder; Alzheimer Dementia; Traumatic Brain Injury

Treatments: Device: Radioligand 18F-AV-1451; Device: PET; Device: MRI; Device: 18F-Florbetapir

Study type: Interventional

Funder types: Other

Identifiers

NCT03641768

Pro00100030

Details and patient eligibility

About

The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain. The investigators also want to learn how PTSD and mild traumatic brain injury can affect the chance of developing Alzheimer disease later in life. The investigators will study this by using magnetic resonance imaging and positron emission tomography scans to obtain pictures of the brain.

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 to 65
• Previously enrolled in studies of OEF/OIF veterans by the same investigators
• Free of implanted metal objects or mental shards in eyes
• Fluent in English and capable of consenting

Exclusion criteria

• Axis I disorders other than Major Depressive Disorder or PTSD
• Current substance abuse or lifetime substance dependence (other than nicotine)
• High risk for suicide
• Claustrophobia
• Neurological disorders
• Learning disability or developmental delay
• Major medical conditions

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 4 patient groups

Healthy volunteers

Active Comparator group

Description:

Volunteers with no trauma history

Treatment:

Device: 18F-Florbetapir

Device: MRI

Device: Radioligand 18F-AV-1451

Device: PET

Trauma only

Active Comparator group

Description:

Volunteers that do not have PTSD but have had similar trauma to those with PTSD

Treatment:

Device: 18F-Florbetapir

Device: MRI

Device: Radioligand 18F-AV-1451

Device: PET

PTSD only

Active Comparator group

Description:

Volunteers with PTSD but no traumatic brain injury

Treatment:

Device: 18F-Florbetapir

Device: MRI

Device: Radioligand 18F-AV-1451

Device: PET

PTSD and TBI

Active Comparator group

Description:

Volunteers with PTSD and mild traumatic brain injury

Treatment:

Device: 18F-Florbetapir

Device: MRI

Device: Radioligand 18F-AV-1451

Device: PET