Risk Stratification and Early Prevention Strategies for Non-compaction of Ventricular Myocardium (CAPTAIN)

Xi'an Jiaotong University

Status: Not yet enrolling

Conditions: Isolated Noncompaction of the Ventricular Myocardium

Treatments: Biological: Diagnosis of NVM

Study type: Observational

Funder types: Other

Identifiers

NCT06504056

XJTU1AF2024LSYY-053

Details and patient eligibility

About

This study intends to retrospectively-prospectively enroll NVM patients from multiple centers to establish a natural population cohort of NVM patients. By collecting clinical data and biological samples from surgical patients, the investigators will construct a prognosis prediction system for NVM, optimize risk stratification, explore new strategies for the early prevention and treatment of NVM, and improve the efficiency of clinical treatment of NVM patients.

Full description

This study intends to retrospectively-prospectively enroll NVM patients from multiple centers to establish a natural population cohort of NVM patients. By collecting clinical data and biological samples from surgical patients, the investigators will construct a prognosis prediction system for NVM, optimize risk stratification, explore new strategies for the early prevention and treatment of NVM, and improve the efficiency of clinical treatment of NVM patients.

Enrollment: 2,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• The diagnosis of nvm was confirmed by cardiac ultrasound, electrocardiogram, magnetic resonance angiography, pathological examination and gene sequencing.
• Patients or their families agreed to participate in the study and authorized informed consent.

Exclusion criteria

• Incomplete clinical data.
• Do not agree to the inclusion or refuse to authorize the informed consent.

Trial design

2,000 participants in 3 patient groups

Left ventricle group

Description:

The patients mainly had thickened myocardial wall with a thin, compacted epicardial layer and a thicker endocardial layer, and were diagnosed with LVNC.

Treatment:

Biological: Diagnosis of NVM

Biological: Diagnosis of NVM

Biological: Diagnosis of NVM

Right ventricle group

Description:

The patients mainly had thickened myocardial wall with a thin, compacted epicardial layer and a thicker endocardial layer, and were diagnosed with right NVM.

Treatment:

Biological: Diagnosis of NVM

Biological: Diagnosis of NVM

Biological: Diagnosis of NVM

Two sided ventricle group

Description:

The patients mainly had thickened myocardial wall with a thin, compacted epicardial layer and a thicker endocardial layer, and were diagnosed with right and left ventricle NVM.

Treatment:

Biological: Diagnosis of NVM

Biological: Diagnosis of NVM

Biological: Diagnosis of NVM