Risk Taking and Decision-making in Cluster Headache Patients (RiCH)

Leiden University Medical Center (LUMC)

Status: Completed

Conditions: Cluster Headache

Treatments: Diagnostic Test: BART Task

Study type: Observational

Funder types: Other

Identifiers

NCT06410872

NL68327

Details and patient eligibility

About

Since there is conflicting and insufficient data regarding CH personality and addictive behaviour, the investigators will investigate risk- and reward seeking behaviour in people with cluster headache. If an increased tendency towards this behaviour is shown, it will add to the clinical knowledge of cluster headache and possible lead to insights in a common biological susceptibility.

Full description

Cluster headache is a severe primary headache disorder. In clinical anecdotes, people with cluster headache frequently report use of tobacco and illicit drugs. Furthermore, addictive behaviours and tattoos are considered to be more common in people with cluster headache than in the general population. The causality of these associations remains unclear. A common biological susceptibility has been proposed, predisposing people to both addictive behaviour and cluster headache. On the other hand, a role of illicit drug exposure in cluster headache pathophysiology has been suggested. The increased use of tobacco and illicit drugs could also reflect attempts to treat cluster headache attacks. In this explorative study the investigators will assess both subjective and objective measures reflecting addictive behaviour and risk- and reward seeking in cluster headache. This will add to the clinical knowledge of cluster headache and possible lead to insights in a common biological susceptibility.

Enrollment: 140 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-64 years
• Normal or corrected vision with acuity up to 20/60
• Presence of episodic (n=35) or chronic (n=35) cluster headache or migraine with or without arua (n=35), diagnosed according to the International Classification of Headache Disorders criteria, 3rd edition (ICHD-3, 3.1.1)

Exclusion criteria

• Diagnosis of uncorrected visual problems (myopia/presbiopia, peripheral vision problems or legal blindness)
• Current diagnosis of generalized anxiety disorder, depression or other psychiatric illness
• Other acute, unstable medical conditions or serious chronic diagnoses

Trial design

140 participants in 4 patient groups

Episodic cluster headache

Description:

Patients diagnosed according to ICHD3 criteria with episodic cluster headache

Treatment:

Diagnostic Test: BART Task

Chronic cluster headache

Description:

Patients diagnosed according to ICHD3 criteria with chroniccluster headache

Treatment:

Diagnostic Test: BART Task

Migraine

Description:

Patients diagnosed according to ICHD3 criteria with migraine (MA and MO)

Treatment:

Diagnostic Test: BART Task

Healthy controls

Description:

Healthy controls, sex- and age-matched without current diagnosis of headache disorder

Treatment:

Diagnostic Test: BART Task