Risk Taking and Fracture Study

Canadian Institutes of Health Research (CIHR)

Status: Completed

Conditions: Fracture

Treatments: Other: Fracture - Boys; Other: Non Fracture - Girls; Other: Non Fracture - Boys; Other: Fracture - Girls

Study type: Observational

Funder types: Other

Identifiers

NCT01768598

H10-00044

Details and patient eligibility

About

Boys suffer a disproportionately large number of fractures compared to girls (55-60%). This study aims to determine why this is the case by identifying risk factors for wrist fractures. The increase in fracture during childhood and adolescence may be associated with 1) risk-taking behaviour in boys, 2) obesity trends in boys during childhood and adolescence, and/or 3) impaired acquisition of bone strength during childhood and adolescence. Importantly from a knowledge translation perspective, modifiable factors such as behaviour, dietary habits or physical activity in boys may predict fracture.

The investigators will measure 400 children (100 girls and 100 boys who have sustained a fracture; 100 same age and sex friends) across 4 years of growth. This study will assess risk behaviours, diet, physical activity, motor proficiency (i.e., balance and coordination), fat and muscle mass and bone strength to determine if there are, 1) differences in whether all or some of these factors predict fractures in boys compared with girls and, 2) whether these factors track forward similarly in boys compared with girls as children advance through the growth spurt.

Full description

The investigators aim to better characterize factors that contribute to fracture in boys and girls and to assess whether such factors track across a four year period. The innovation is to use novel methods and an integrated approach, to measure the influence of risk-taking behaviour, body composition, bone microstructure, motor proficiency, diet and physical activity in one model across growth. This will provide a more comprehensive picture of the key multi-factorial predictors of fracture within- and between-sexes. This essential information will provide the basis for change in public health policy, clinical practice, community programs, and targeted interventions.

Enrollment: 319 patients

Sex: All

Ages: 8 to 15 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Boys aged 9-15 and Girls aged 8-13
• Fracture to distal radius after low to moderate energy trauma
• No other health concerns
• Healthy (non fracture) subjects for comparison

Exclusion criteria

• Fracture is a result of severe trauma
• Children with ontological medical conditions

Trial design

319 participants in 4 patient groups

Fracture - Boys

Description:

Boys who have sustained a distal radius fracture

Treatment:

Other: Fracture - Boys

Fracture - Girls

Description:

Girls who have sustained a distal radius fracture

Treatment:

Other: Fracture - Girls

Non Fracture - Boys

Description:

Boys who have not sustained a distal radius fracture

Treatment:

Other: Non Fracture - Boys

Non Fracture - Girls

Description:

Girls who have not sustained a distal radius fracture

Treatment:

Other: Non Fracture - Girls