Risky Decision Making in Methamphetamine Users: The Role of Opioid Blockade

Oregon Health & Science University (OHSU)

Status: Completed

Conditions: HIV; Methamphetamine Abuse

Treatments: Drug: Extended release naltrexone; Drug: Placebo

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01822132

1R21DA033182-01A1 (U.S. NIH Grant/Contract)

ALKIIT-KOR-034

Details and patient eligibility

About

The purpose of this protocol is to learn more about impulsive decision making in people who use methamphetamines. The investigators would like to know if a medication called naltrexone changes how people make decisions. The investigators would also like to know whether changes in decision making can be observed by MRI (magnetic resonance imaging).

The research is conducted in Portland, OR.

Enrollment: 76 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Summary Inclusion Criteria:

• Diagnostic and Statistical Manual (DSM)-IV Methamphetamine Dependence
• Deemed healthy enough to participate by study physician
• Age 18-55
• Right handed
• English-speaking

Summary Exclusion Criteria:

• Current opioid use in the last 30 days; opioid abuse or dependence within past 5 years
• Pregnancy
• MRI contraindications (e.g. metal in head).

The research is conducted in Portland, OR.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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76 participants in 2 patient groups, including a placebo group

Extended release naltrexone

Experimental group

Description:

One dose of intramuscular injection of 380mg extended-release naltrexone.

Treatment:

Drug: Extended release naltrexone

Placebo

Placebo Comparator group

Description:

One dose of intramuscular injection of placebo.

Treatment:

Drug: Placebo