RNA Biomarkers in Tissue Samples From Infants With Acute Myeloid Leukemia

Children's Oncology Group

Status

Completed

Conditions

Leukemia

Treatments

Genetic: reverse transcriptase-polymerase chain reaction

Genetic: nucleic acid sequencing

Genetic: RNA analysis

Other: laboratory biomarker analysis

Study type

Observational

Funder types

NETWORK

NIH

Identifiers

NCT01229124

AAML11B1 (Other Identifier)

COG-AAML11B1 (Other Identifier)

NCI-2011-02841 (Registry Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in RNA and identify biomarkers related to cancer.

PURPOSE: This research study is studying RNA biomarkers in tissue samples from infants with acute myeloid leukemia.

Full description

OBJECTIVES:

Sequence the microRNAs present in 20 infant AML samples as a pilot study.
Compare microRNAs present in infant AML samples to infant ALL samples that are being concurrently sequenced in a separate study to identify lineage- and translocation-specific microRNAs.

OUTLINE: This is a multicenter study.

Previously collected cryopreserved cells from diagnosis are sequenced using reverse transcriptase-PCR.

Enrollment

20 estimated patients

Sex

All

Ages

Under 1 year old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS: