RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis

University of Maryland Baltimore (UMB)

Status: Enrolling

Conditions: Subglottic Stenosis; Tracheal Stenosis

Treatments: Procedure: Biopsy or surgery

Study type: Observational

Funder types: Other

Identifiers

NCT07258784

HP-00114191

Details and patient eligibility

About

Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endoscopic or surgical interventions to open up the airways. This project will analyze resected or biopsied tissue from patients with benign tracheal stenosis to define disease-specific RNA expression profiles.

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with benign tracheal stenosis

Exclusion criteria

• Malignancy. active infection

Trial design

10 participants in 1 patient group

patients with benign tracheal stenosis undergoing either endoscopic or surgical treatment

Treatment:

Procedure: Biopsy or surgery