Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane

Tianjin Medical University

Status: Completed

Conditions: Neuromuscular Monitoring

Treatments: Drug: MAC 0.75; Drug: Etomidate; Drug: MAC 1.0; Drug: MAC 0.5; Drug: Rocuronium; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT02711917

Narina Goulvaden (Other Identifier)

TianjinMUGH

Details and patient eligibility

About

Different concentration of sevoflurane was given to maintain anesthesia. The dose of propofol to maintain BIS between 40-60 and the consumption of rocuronium was recorded and evaluated.

Full description

2 age group of patients was selected, 40-60 years and above 60 years. Maintenance of anesthesia was carried out using different concentration of Sevoflurane, ie MAC 0.5, 0.75 and 1.0. Bis value was kept between 40-60 and the dose of propofol required was recorded. Rocuronium infusion given in a close loop infusion system for different group was tabulated. The results was then analysed.

Enrollment: 175 patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI < 30
• elective Gynaecological/abdominal/urological surgery
• Operation time < 3hrs
• ASA I/II
• Intubated patients

Exclusion criteria

• Coronary artery disease, cardiac, lung, hepatic and renal insufficiency
• Severe uncontrolled HBP
• Obesity (BMI >30)
• Neuromuscular and metabolic diseases
• Receiving medication known to influence neuromuscular transmission
• Pregnancy
• Psychiatric disorders
• Allergy history to any of the drugs that will be used

Trial design

175 participants in 8 patient groups

SP1- sevoflurane MAC 0.5

Experimental group

Description:

In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.5. Propofol infusion is started to keep BIS between 40-60.

Treatment:

Drug: Propofol

Drug: Rocuronium

Drug: MAC 0.5

SP2- Sevoflurane MAC 0.75

Experimental group

Description:

In this group, patient of age 40-60 years, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen.Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.75. Propofol infusion is started to keep BIS between 40-60.

Treatment:

Drug: Propofol

Drug: Rocuronium

Drug: MAC 0.75

SP3 -Sevoflurane MAC 1.0

Experimental group

Description:

In this group, patient of age 40-60 years, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 1.0. Propofol infusion is started to keep BIS between 40-60.

Treatment:

Drug: Propofol

Drug: MAC 1.0

Drug: Rocuronium

SP4- Sevoflurane MAC 0.5

Experimental group

Description:

In this group, patient above 60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Propofol infusion is started to keep BIS between 40-60.

Treatment:

Drug: Propofol

Drug: Rocuronium

Drug: MAC 0.5

SP5- Sevoflurane MAC 0.75

Experimental group

Description:

In this group, patient above 60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.75. Propofol infusion is started to keep BIS between 40-60.

Treatment:

Drug: Propofol

Drug: Rocuronium

Drug: MAC 0.75

SE1- Sevoflurane MAC 0.5

Experimental group

Description:

In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60.

Treatment:

Drug: Etomidate

Drug: Rocuronium

Drug: MAC 0.5

SE2- Sevoflurane 0.75

Experimental group

Description:

In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60.

Treatment:

Drug: Etomidate

Drug: Rocuronium

Drug: MAC 0.75

SE3- Sevoflurane MAC 1.0

Experimental group

Description:

In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60.

Treatment:

Drug: MAC 1.0

Drug: Etomidate

Drug: Rocuronium